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Surfactant Associated Protein C (SPC)

SFTPC; PSP-C; SFTP2; SP-C; SP5; Pulmonary Surfactant Protein C; Pulmonary surfactant-associated proteolipid SPL(Val)

  • SP-C is a fragment of a much larger precursor protein of 21 kD. The precursor contains an exceedingly hydrophobic region of 34 amino acids that comprises most of the mature SP C, and a unique poly-valine domain.Pulmonary surfactant-associated protein C is a membrane protein which manufactures surfactant.Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.The SFTPC gene encodes pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. It is produced exclusively by type II alveolar epithelial cells in the lung. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V213Hu01 Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies MV213Hu22 Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
PV213Hu01 Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits KEV213Hu ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V213Mu02 Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
PV213Mu01 Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits KEV213Mu ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V213Ra01 Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies MV213Ra21 Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
PV213Ra01 Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits KEV213Ra ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Surfactant Associated Protein C (SPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Surfactant Associated Protein C (SPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Surfactant Associated Protein C (SPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Surfactant Associated Protein C (SPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Surfactant Associated Protein C (SPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Surfactant Associated Protein C (SPC) CLIA assay for Antigen Detection

Reference

"Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences."
Proc. Natl. Acad. Sci. U.S.A. 84:7915-7919(1987) [PubMed] [Europe PMC] [Abstract]

"cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)."
J. Biol. Chem. 263:9-12(1988) [PubMed] [Europe PMC] [Abstract]

"Two SP-C genes encoding human pulmonary surfactant proteolipid."
J. Biol. Chem. 263:10326-10331(1988) [PubMed] [Europe PMC] [Abstract]

"Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species."
Exp. Lung Res. 20:57-72(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms."
FEBS Lett. 232:61-64(1988) [PubMed] [Europe PMC] [Abstract]

"Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups."
Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990) [PubMed] [Europe PMC] [Abstract]

"High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C."
Proc. Natl. Acad. Sci. U.S.A. 109:2325-2329(2012) [PubMed] [Europe PMC] [Abstract]

"Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred."
Am. J. Respir. Crit. Care Med. 165:1322-1328(2002) [PubMed] [Europe PMC] [Abstract]

"Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease."
Am. J. Med. Genet. A 126:18-26(2004) [PubMed] [Europe PMC] [Abstract]

"Surfactant protein C gene variation in the Finnish population -association with perinatal respiratory disease."
Eur. J. Hum. Genet. 12:312-320(2004) [PubMed] [Europe PMC] [Abstract]

"Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene."
Eur. Respir. J. 24:30-39(2004) [PubMed] [Europe PMC] [Abstract]

"Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation."
Eur. Respir. J. 24:1072-1073(2004) [PubMed] [Europe PMC] [Abstract]

"Hydroxychloroquine and surfactant protein C deficiency."
N. Engl. J. Med. 352:207-208(2005) [PubMed] [Europe PMC] [Abstract]

"Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene."
Pediatr. Res. 57:89-98(2005) [PubMed] [Europe PMC] [Abstract]