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Potassium Chloride Cotransporters 4 (KCC4)

SLC12A7; Solute Carrier Family 12(Potassium/Chloride Transporters)Member 7; Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4

By searching EST databases, Mount et al. (1999) identified a cDNA encoding SLC12A7, which they initially termed KCC3 but later renamed KCC4. The deduced 1,083-amino acid SLC12A7 protein contains 12 membrane-spanning segments, 8 phosphorylation sites, 7 of which are in the C terminus, and 4 potential N-glycosylation sites.

SLC12A7 shares 65% amino acid identity with SLC12A4 and 66% identity with SLC12A6 . Northern blot analysis detected a 5.3-kb SLC12A7 transcript in most tissues tested, with highest expression in heart and kidney and little or no expression in adult brain. Functional analysis confirmed that SLC12A7 is a KCC.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Hu01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Hu01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Hu01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Hu01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Hu01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Mu01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Mu01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Mu01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Mu01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Mu01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Ra01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Ra01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Ra01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Ra01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Ra01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Ca01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Ca01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Ca01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Ca01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Ca01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Po01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Po01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Po01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Po01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Po01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Bo01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Bo01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Bo01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Bo01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Bo01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Rb01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Rb01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Rb01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Rb01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Rb01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV209Mo01 Recombinant Potassium Chloride Cotransporters 4 (KCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV209Mo01 Monoclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IP.
PAV209Mo01 Polyclonal Antibody to Potassium Chloride Cotransporters 4 (KCC4) WB; IHC; ICC; IF.
Assay Kits CLV209Mo01 CLIA Kit for Potassium Chloride Cotransporters 4 (KCC4) CLIA assay for Antigen Detection
ELV209Mo01 ELISA Kit for Potassium Chloride Cotransporters 4 (KCC4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family."
J. Biol. Chem. 274:16355-16362(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of long cDNA clones from human adult spleen."
DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4."
J. Biol. Chem. 275:30326-30334(2000) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Similar Effects of all WNK3 Variants upon SLC12 Cotransporters."
Am. J. Physiol. 301:C601-C608(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]