Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2)
C14orf141; LTBP3
LTBP2 belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.LTBP2 has approximately 45% amino acid identity to LTBP1 and 25% identity to fibrillin-1 (FBN1) but unlike other LTBP family members does not bind to latent forms of TGFB. The C-terminal region of LTBP2 competes with LTBP1 for specific binding to the N-terminal region of FBN1, but not FBN2 , in microfibrils.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Hu01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Hu01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Hu01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Hu01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Hu01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Mu01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Mu01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Mu01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Mu01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Mu01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Ra01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Ra01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Ra01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Ra01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Ra01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Ca01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Ca01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Ca01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Ca01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Ca01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Po01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Po01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Po01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Po01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Po01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Bo01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Bo01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Bo01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Bo01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Bo01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Rb01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Rb01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Rb01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Rb01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Rb01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV206Mo01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV206Mo01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IP. |
| PAV206Mo01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV206Mo01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | CLIA assay for Antigen Detection |
| ELV206Mo01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein."
J. Biol. Chem. 269:32469-32478(1994) [PubMed] [Europe PMC] [Abstract]
"Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2."
Int. J. Biochem. Cell Biol. 28:531-542(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta."
Mol. Biol. Cell 11:2691-2704(2000) [PubMed] [Europe PMC] [Abstract]
"Latent transforming growth factor-beta binding proteins (LTBPs) --structural extracellular matrix proteins for targeting TGF-beta action."
Cytokine Growth Factor Rev. 10:99-117(1999) [PubMed] [Europe PMC] [Abstract]
"The latent transforming growth factor beta binding protein (LTBP) family."
Biochem. J. 352:601-610(2000) [PubMed] [Europe PMC] [Abstract]
"Null mutations in LTBP2 cause primary congenital glaucoma."
Am. J. Hum. Genet. 84:664-671(2009) [PubMed] [Europe PMC] [Abstract]
"A homozygous mutation in LTBP2 causes isolated microspherophakia."
Hum. Genet. 128:365-371(2010) [PubMed] [Europe PMC] [Abstract]
"LTBP-2 has multiple heparin/heparan sulfate binding sites."
Matrix Biol. 29:393-401(2010) [PubMed] [Europe PMC] [Abstract]
"LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix."
Hum. Mutat. 33:1182-1187(2012) [PubMed] [Europe PMC] [Abstract]