Prostaglandin D2 Synthase, Hematopoietic (PTGDS)

HPGDS; GSTS; H-PGDS; PDS; PGD2; PGDS; PGDS2; Glutathione S-Transferase Sigma; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase

SPN	V198
HGNC	17890
MGI	1859384
PubMed	22370065
RGD	69251
UniProt	O60760
Wiki	PTGDS

Prostaglandin D synthase catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).

Prostaglandin D synthase induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin type enzyme (b-trace) and the hematopoietic enzyme. Lipocalin type prostaglandin D synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as b-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic prostaglandin D synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes.

Reference

"Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase."
Eur. J. Biochem. 267:3315-3322(2000) [PubMed] [Europe PMC] [Abstract]

"Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases."
Biochem. J. 359:507-516(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester."
Biochem. Biophys. Res. Commun. 241:288-293(1997) [PubMed] [Europe PMC] [Abstract]

"Prostaglandin D synthase in human megakaryoblastic cells."
J. Biol. Chem. 272:28263-28266(1997) [PubMed] [Europe PMC] [Abstract]

"Mechanism of metal activation of human hematopoietic prostaglandin D synthase."
Nat. Struct. Biol. 10:291-296(2003) [PubMed] [Europe PMC] [Abstract]

"First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase."
J. Biochem. 135:279-283(2004) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase."
J. Biol. Chem. 281:15277-15286(2006) [PubMed] [Europe PMC] [Abstract]

"Novel prostaglandin D synthase inhibitors generated by fragment-based drug design."
J. Med. Chem. 51:2178-2186(2008) [PubMed] [Europe PMC] [Abstract]

"Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase."
Eur. J. Med. Chem. 45:447-454(2010) [PubMed] [Europe PMC] [Abstract]