Interleukin 13 Receptor Alpha 2 (IL13Ra2)

CD213A2; CD213-A2; IL13R-A2; IL13-RA2; IL13-R; IL13-BP

SPN	V195
HGNC	5975
MGI	1277954
PubMed	16981293
RGD	620838
UniProt	Q14627
Wiki	IL13RA2

Interleukin 13 receptor, alpha 2 is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.

To isolate components of IL13 receptors,Caput et al. (1996) first identified a human renal carcinoma cell line that expressed a high number of IL13-binding proteins. By screening a cDNA library derived from this cell line for the ability to direct synthesis of a cell surface IL13-binding protein, Caput et al. (1996) isolated cDNAs encoding IL13RA2, called IL13R by them. Human cells expressing IL13RA2 showed specific IL13 binding.

Reference

"Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain."
J. Biol. Chem. 271:16921-16926(1996) [PubMed] [Europe PMC] [Abstract]

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Genomics 42:141-145(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]