Fatty Acid Transport Protein 5 (FATP5)

SLC27A5; ACSB; ACSVL6; FACVL3; VLACSR; BACS; VLCSH2; Fatty Acid Coenzyme A Ligase Very Long Chain 3; Solute Carrier Family 27 Member 5; Bile Acyl CoA Synthetase

SPN	V178
HGNC	10999
MGI	1347100
PubMed	16618416
RGD	708535
UniProt	Q9Y2P5
Wiki	SLC27A5

Very long chain fatty acid synthetase (VLACS, or SLC27A2), an enzyme whose function is presumed missing in ALD, is highly expressed in liver and kidney, but is expressed at much lower levels in brain. However, brain contains high amounts of VLCFA and is the organ most affected in ALD. In an attempt to isolate a VLACS isoform with a different tissue distribution, Berger et al. (1998) used degenerate PCR to clone a mouse cDNA and a partial human cDNA encoding a VLACS-related protein, termed VLACSR. VLACSR is 43% identical to mouse VLACS and 37% identical to mouse FATP. Northern blot analysis of mouse tissues revealed that a 2.6-kb VLACSR mRNA was highly abundant in liver. Smaller VLACSR transcripts were present at low levels in brain, lung, testis, spleen, and skeletal muscle.

Reference

"Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein."
Mol. Genet. Metab. 68:32-42(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase."
J. Biol. Chem. 275:15605-15608(2000) [PubMed] [Europe PMC] [Abstract]

"Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling."
J. Biol. Chem. 277:24771-24779(2002) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]