Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)

TNFRSF18; AITR; Tumor Necrosis Factor Receptor Superfamily 18; Glucocorticoid-induced TNFR-related protein; Activation-inducible TNFR family receptor

SPN	V176
HGNC	11914
MGI	894675
PubMed	12070049
UniProt	Q9Y5U5
Wiki	TNFRSF18

GITR (glucocorticoid-induced tumor necrosis factor receptor) is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells. In mouse models, GITR was initially noted to be selectively enriched on the surface of regulatory T cells, making this an attractive potential surface marker for these rare cells. However, subsequent studies revealed GITR to also be up-regulated on any activated T cells in humans, thus undermining its utility as a regulatory T cell marker.Members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies, such as TNFRSF18, regulate diverse biologic functions, including cell proliferation, differentiation, and survival. For further background information on the TNF and TNFR superfamilies.

Reference

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Curr. Biol. 9:215-218(1999) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of three novel mRNA splice variants of GITR."
Cell Death Differ. 7:408-410(2000) [PubMed] [Europe PMC] [Abstract]

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