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Protein Kinase, AMP Activated Beta 1 (PRKAb1)

AMPK; HAMPKb; 5'-AMP-Activated Protein Kinase Subunit Beta-1 Non-Catalytic Subunit; Adenosine Monophosphate Activated Protein Kinase(AMPK)

5'-AMP-activated protein kinase subunit beta-1 is  a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Hu01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Hu01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Hu01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Hu01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Hu01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Mu01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Mu01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Mu01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Mu01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Mu01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Ra01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Ra01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Ra01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Ra01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Ra01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Ca01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Ca01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Ca01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Ca01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Ca01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Po01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Po01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Po01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Po01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Po01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Bo01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Bo01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Bo01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Bo01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Bo01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Rb01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Rb01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Rb01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Rb01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Rb01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV167Mo01 Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV167Mo01 Monoclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IP.
PAV167Mo01 Polyclonal Antibody to Protein Kinase, AMP Activated Beta 1 (PRKAb1) WB; IHC; ICC; IF.
Assay Kits CLV167Mo01 CLIA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) CLIA assay for Antigen Detection
ELV167Mo01 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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"Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."
Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]

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"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
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"AMPK is a direct adenylate charge-regulated protein kinase."
Science 332:1433-1435(2011) [PubMed] [Europe PMC] [Abstract]

"AMP-activated protein kinase in metabolic control and insulin signaling."
Circ. Res. 100:328-341(2007) [PubMed] [Europe PMC] [Abstract]

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]