Prion Protein (PRNP)
CD230; GSS; ASCR; CJD; PRIP; PrP; PrP2730; PrPc; Major prion protein; Creutzfeldt-Jakob Disease; Gerstmann-Strausler-Scheinker Syndrome; Fatal Familial Insomnia
PRNP is a gene that codes for a protein called the prion protein (PrP), which is expressed in the brain and several other tissues.The human PRNP gene is located on the short (p) arm of chromosome 20 between the end (terminus) of the arm and position 12, from base pair 4,615,068 to base pair 4,630,233. PRNP has also recently been designated CD230 (cluster of differentiation 230).
Although the precise function of PrP is not yet known, it is possibly involved in the transport of ionic copper to cells from the surrounding environment. Researchers have also proposed roles for PrP in cell signaling or in the formation of gaps between nerve cells (synapses) where cell-to-cell communication occurs.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Hu01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Hu01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Hu01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Hu01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Hu01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Mu01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Mu01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Mu01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Mu01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Mu01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Ra01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Ra01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Ra01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Ra01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Ra01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Ca01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Ca01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Ca01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Ca01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Ca01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Po01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Po01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Po01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Po01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Po01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Bo01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Bo01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Bo01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Bo01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Bo01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Rb01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Rb01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Rb01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Rb01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Rb01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV159Mo01 | Recombinant Prion Protein (PRNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV159Mo01 | Monoclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IP. |
| PAV159Mo01 | Polyclonal Antibody to Prion Protein (PRNP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV159Mo01 | CLIA Kit for Prion Protein (PRNP) | CLIA assay for Antigen Detection |
| ELV159Mo01 | ELISA Kit for Prion Protein (PRNP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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PLoS Pathog. 5:E1000666-E1000666(2009) [PubMed] [Europe PMC] [Abstract]
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"Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3."
J. Biol. Chem. 285:21004-21012(2010) [PubMed] [Europe PMC] [Abstract]
"Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment."
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Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 97:145-150(2000) [PubMed] [Europe PMC] [Abstract]
"NMR structures of three single-residue variants of the human prion protein."
Proc. Natl. Acad. Sci. U.S.A. 97:8340-8345(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human prion protein reveals a mechanism for oligomerization."
Nat. Struct. Biol. 8:770-774(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular features of the copper binding sites in the octarepeat domain of the prion protein."
Biochemistry 41:3991-4001(2002) [PubMed] [Europe PMC] [Abstract]
"The octapeptide repeats in mammalian prion protein constitute a pH-dependent folding and aggregation site."
J. Mol. Biol. 334:477-488(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 447:453-457(2007) [PubMed] [Europe PMC] [Abstract]
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"Conformational diversity in prion protein variants influences intermolecular beta-sheet formation."
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"Pro-->Leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Straussler syndrome."
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Neurology 42:669-670(1992) [PubMed] [Europe PMC] [Abstract]
"New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred."
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"A new point mutation of the prion protein gene in Creutzfeldt-Jakob disease."
Ann. Neurol. 34:802-807(1993) [PubMed] [Europe PMC] [Abstract]
"A missense mutation at codon 105 with codon 129 polymorphism of the prion protein gene in a new variant of Gerstmann-Straussler-Scheinker disease."
Neurology 43:2723-2724(1993) [PubMed] [Europe PMC] [Abstract]
"A variant of Gerstmann-Straussler-Scheinker disease carrying codon 105 mutation with codon 129 polymorphism of the prion protein gene: a clinicopathological study."
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"Japanese family with Creutzfeldt-Jakob disease with codon 200 point mutation of the prion protein gene."
Neurology 44:299-301(1994) [PubMed] [Europe PMC] [Abstract]
"Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease."
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"Gerstmann-Straussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients."
Neurology 45:1127-1134(1995) [PubMed] [Europe PMC] [Abstract]
"Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Straussler-Scheinker disease (PrP-P102L mutation)."
Neurology 47:734-741(1996) [PubMed] [Europe PMC] [Abstract]
"Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease."
Neurology 47:1305-1312(1996) [PubMed] [Europe PMC] [Abstract]
"Familial spongiform encephalopathy associated with a novel prion protein gene mutation."
Ann. Neurol. 42:138-146(1997) [PubMed] [Europe PMC] [Abstract]
"Phenotypic variability of Gerstmann-Straussler-Scheinker disease is associated with prion protein heterogeneity."
J. Neuropathol. Exp. Neurol. 57:979-988(1998) [PubMed] [Europe PMC] [Abstract]
"Molecular genetics of human prion diseases in Germany."
Hum. Genet. 105:244-252(1999) [PubMed] [Europe PMC] [Abstract]
"High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes."
Am. J. Hum. Genet. 66:110-117(2000) [PubMed] [Europe PMC] [Abstract]
"Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype."
Hum. Mutat. 15:482-482(2000) [PubMed] [Europe PMC] [Abstract]
"A new PRNP mutation (G131V) associated with Gerstmann-Straussler-Scheinker disease."
Arch. Neurol. 58:1899-1902(2001) [PubMed] [Europe PMC] [Abstract]