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Immunoglobulin G2 (IgG2)

IGHG2; Ig Gamma-2 Chain C Region; Immunoglobulin Heavy Constant Gamma 2; G2m Marker; Immunoglobulin Gm2

Oxelius et al. (1981) pointed out that deficiency of IgG2 in combination with IgA deficiency is a critical factor in whether or not IgA-deficient persons have illness (frequent infections, autoimmune disorders, atopy, malabsorption). No allotypes are known on gamma-4 or on gamma-2. The reason may be the test system. Anti-D antiserum is used and this antibody is usually gamma-1 or gamma-3. Patients with IgG2 deficiency have recurrent sinopulmonary infections caused by Pneumococcus and Hemophilus. Tashita et al. (1998) studied 2 Japanese brothers, ages 5 and 10 years and found that both brothers were homozygous for a 1-bp insertion (1793insG) in exon 4 of the IGHG2 gene, just upstream from the alternative splice site for M exons . IgG2 23%; no Crosses placenta easily; third highest Complement activator; extremely low affinity Binds to Fc receptor on phagocytic cells

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Hu01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Hu01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Hu01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Hu01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Hu01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Mu01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Mu01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Mu01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Mu01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Mu01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Ra01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Ra01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Ra01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Ra01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Ra01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Ca01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Ca01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Ca01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Ca01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Ca01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Po01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Po01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Po01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Po01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Po01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Bo01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Bo01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Bo01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Bo01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Bo01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Rb01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Rb01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Rb01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Rb01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Rb01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV157Mo01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV157Mo01 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
PAV157Mo01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CLV157Mo01 CLIA Kit for Immunoglobulin G2 (IgG2) CLIA assay for Antigen Detection
ELV157Mo01 ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes."
Proc. Natl. Acad. Sci. U.S.A. 79:1984-1988(1982) [PubMed] [Europe PMC] [Abstract]

"Structure of human immunoglobulin gamma genes: implications for evolution of a gene family."
Cell 29:671-679(1982) [PubMed] [Europe PMC] [Abstract]

"Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes."
EMBO J. 1:403-407(1982) [PubMed] [Europe PMC] [Abstract]

"The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications."
J. Immunol. 125:1048-1054(1980) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein."
Can. J. Biochem. 57:758-767(1979) [PubMed] [Europe PMC] [Abstract]

"A note of the amino acid sequence of residues 381-391 of human immunoglobulins gamma chains."
Mol. Immunol. 16:923-925(1979) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-1980) to the PIR data bank

"Characterization of the two unique human anti-flavin monoclonal immunoglobulins."
Eur. J. Biochem. 228:886-893(1995) [PubMed] [Europe PMC] [Abstract]

"Disulphide bridges of the heavy chain of human immunoglobulin G2."
Biochem. J. 121:217-225(1971) [PubMed] [Europe PMC] [Abstract]

"Structural studies of immunoglobulin G."
Nature 221:145-148(1969) [PubMed] [Europe PMC] [Abstract]

"A proteomic analysis of human bile."
Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]