Suppressors Of Cytokine Signaling 3 (SOCS3)

ATOD4; CIS3; Cish3; MGC71791; SOCS-3; SSI-3; SSI3; Cytokine-inducible SH2 protein 3; STAT-induced STAT inhibitor 3

SPN	V155
HGNC	19391
MGI	1201791
PubMed	12560330
RGD	621087
UniProt	O14543
Wiki	SOCS3

SOCS-3 is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity and thereby suppressing cytokine signaling. It is a member of the STAT-induced STAT inhibitor (SSI). To date, there are eight members of SOCS family that have been recognized. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain and a previously unrecognized C-terminal motif that has been called the SOCS box. The expression of the SOCS-3 gene is induced by various cytokines, including IL-6, IL-10, and interferon (IFN)-gamma. Studies of the mouse counterpart of the SOCS-3 gene suggested this gene is involved in the negative regulation of fetal liver hematopoiesis, and placental development.

Reference

"Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
Biochem. Biophys. Res. Commun. 237:79-83(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of novel CIS family genes."
Biochem. Biophys. Res. Commun. 239:439-446(1997) [PubMed] [Europe PMC] [Abstract]

"Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor."
Biochem. Biophys. Res. Commun. 278:38-43(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain."
Genes Cells 4:339-351(1999) [PubMed] [Europe PMC] [Abstract]

"A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor."
Eur. J. Biochem. 269:2516-2526(2002) [PubMed] [Europe PMC] [Abstract]

"SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit."
Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract]

"Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation."
Blood 103:2997-3004(2004) [PubMed] [Europe PMC] [Abstract]

"VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases."
Genes Dev. 18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract]

"Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis."
Am. J. Hum. Genet. 78:1060-1065(2006) [PubMed] [Europe PMC] [Abstract]

"Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling."
J. Cell Sci. 119:380-387(2006) [PubMed] [Europe PMC] [Abstract]

"Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components."
J. Biol. Chem. 287:39800-39811(2012) [PubMed] [Europe PMC] [Abstract]