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Integrin Alpha M (ITGaM)

CD11b; ITG-AM; CR3A; MAC-1; MAC1A; MO1A; Complement Component 3 Receptor 3 Subunit; Cell surface glycoprotein MAC-1 subunit alpha; Neutrophil adherence receptor

Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (alpha M beta 2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of alpha beta 2 is the common integrin beta 2 subunit known as CD18, and integrin alpha M beta 2 thus belongs to the beta 2 subfamily (or leukocyte) integrins alpha M beta 2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells.It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V154Hu01 Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
PV154Hu01 Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
LV154Hu71 Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V154Mu01 Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
PV154Mu01 Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V154Ra01 Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
PV154Ra01 Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits KEV154Ra ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha M (ITGaM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha M (ITGaM) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha M (ITGaM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha M (ITGaM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha M (ITGaM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha M (ITGaM) CLIA assay for Antigen Detection

Reference

"The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]

"The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization of the myeloid-specific CD11b promoter."
Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]

"N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]

"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]

"JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]

"Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]

"Cation binding to the integrin CD11b I domain and activation model assessment."
Structure 6:923-935(1998) [PubMed] [Europe PMC] [Abstract]

"Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]

"A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."
Nat. Genet. 40:152-154(2008) [PubMed] [Europe PMC] [Abstract]

"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci."
Nat. Genet. 40:204-210(2008) [PubMed] [Europe PMC] [Abstract]