Interleukin 21 (IL21)
Za11
Interleukin 21 (IL-21), is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, that is expressed in bone marrow cells and various lymphocytes.
IL-21 is expressed in activated human CD4+ T cells but not in most other tissues. In addition, IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as T follicular cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Hu01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Hu01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Hu01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Hu01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Hu01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Mu01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Mu01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Mu01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Mu01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Mu01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Ra01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Ra01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Ra01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Ra01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Ra01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Ca01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Ca01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Ca01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Ca01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Ca01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Po01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Po01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Po01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Po01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Po01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Bo01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Bo01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Bo01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Bo01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Bo01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Rb01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Rb01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Rb01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Rb01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Rb01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV151Mo01 | Recombinant Interleukin 21 (IL21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV151Mo01 | Monoclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IP. |
| PAV151Mo01 | Polyclonal Antibody to Interleukin 21 (IL21) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV151Mo01 | CLIA Kit for Interleukin 21 (IL21) | CLIA assay for Antigen Detection |
| ELV151Mo01 | ELISA Kit for Interleukin 21 (IL21) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nature 408:57-63(2000) [PubMed] [Europe PMC] [Abstract]
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FEBS Lett. 581:4001-4009(2007) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells."
J. Leukoc. Biol. 76:416-422(2004) [PubMed] [Europe PMC] [Abstract]
"Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses."
Immunology 112:177-182(2004) [PubMed] [Europe PMC] [Abstract]
"The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue."
J. Biol. Chem. 282:23326-23336(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R."
J. Biol. Chem. 287:9454-9460(2012) [PubMed] [Europe PMC] [Abstract]
"Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency."
J. Allergy Clin. Immunol. 133:1651-1660(2014) [PubMed] [Europe PMC] [Abstract]