Permeability Glycoprotein (Pgp)
CD243; ABCB1; ABC20; CLCS; GP170; MDR1; PGY1; P-Glycoprotein; Multidrug resistance protein 1; ATP-Binding Cassette,Sub-Family B(MDR/TAP),Member 1; Colchicin Sensitivity
P-glycoprotein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V149Hu01 | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | MV149Hu22 | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| PV149Hu01 | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| LV149Hu81 | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV149Hu | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V149Mu02 | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| PV149Mu01 | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| LV149Mu71 | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| LV149Mu81 | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV149Mu | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV149Ra | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Permeability Glycoprotein (Pgp) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Permeability Glycoprotein (Pgp) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Permeability Glycoprotein (Pgp) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Permeability Glycoprotein (Pgp) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Permeability Glycoprotein (Pgp) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Permeability Glycoprotein (Pgp) | CLIA assay for Antigen Detection |
Reference
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Cell 47:381-389(1986) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins."
J. Biol. Chem. 265:506-514(1990) [PubMed] [Europe PMC] [Abstract]
"Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
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"ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2."
Pharmacogenomics 2:51-64(2001) [PubMed] [Europe PMC] [Abstract]
"Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function."
Cancer Lett. 345:124-131(2014) [PubMed] [Europe PMC] [Abstract]
"An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene."
Cell 53:519-529(1988) [PubMed] [Europe PMC] [Abstract]
"Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."
Blood 91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
"A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."
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"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo."
Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000) [PubMed] [Europe PMC] [Abstract]
"Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects."
Clin. Pharmacol. Ther. 69:169-174(2001) [PubMed] [Europe PMC] [Abstract]
"Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)."
Drug Metab. Pharmacokinet. 17:479-481(2002) [PubMed] [Europe PMC] [Abstract]
"Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone."
Drug Metab. Pharmacokinet. 17:566-571(2002) [PubMed] [Europe PMC] [Abstract]
"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
"MDR1 Ala893 polymorphism is associated with inflammatory bowel disease."
Am. J. Hum. Genet. 73:1282-1292(2003) [PubMed] [Europe PMC] [Abstract]
Erratum
Am. J. Hum. Genet. 74:1080-1080(2004)
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]