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Keratin 10 (KRT10)

K10; CK10; KPP; Cytokeratin 10; Epidermolytic Hyperkeratosis; Keratosis Palmaris Et Plantaris; Keratin, type I cytoskeletal 10

Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), also known as KRT10, is a human gene.This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins.

Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Hu01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Hu01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Hu01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Hu01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Hu01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Mu01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Mu01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Mu01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Mu01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Mu01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Ra01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Ra01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Ra01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Ra01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Ra01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Ca01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Ca01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Ca01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Ca01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Ca01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Po01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Po01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Po01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Po01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Po01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Bo01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Bo01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Bo01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Bo01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Bo01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Rb01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Rb01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Rb01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Rb01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Rb01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV148Mo01 Recombinant Keratin 10 (KRT10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV148Mo01 Monoclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IP.
PAV148Mo01 Polyclonal Antibody to Keratin 10 (KRT10) WB; IHC; ICC; IF.
Assay Kits CLV148Mo01 CLIA Kit for Keratin 10 (KRT10) CLIA assay for Antigen Detection
ELV148Mo01 ELISA Kit for Keratin 10 (KRT10) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences."
J. Biol. Chem. 263:15584-15589(1988) [PubMed] [Europe PMC] [Abstract]

"Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10."
J. Mol. Biol. 204:841-856(1988) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression."
Mol. Biol. Rep. 12:277-283(1987) [PubMed] [Europe PMC] [Abstract]

"Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing."
J. Invest. Dermatol. 102:13-16(1994) [PubMed] [Europe PMC] [Abstract]

"Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats."
Gene 116:245-251(1992) [PubMed] [Europe PMC] [Abstract]

"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10."
Science 330:94-97(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes."
Cell 70:811-819(1992) [PubMed] [Europe PMC] [Abstract]

"Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops."
Proc. Natl. Acad. Sci. U.S.A. 89:910-914(1992) [PubMed] [Europe PMC] [Abstract]

"Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis."
Science 257:1128-1130(1992) [PubMed] [Europe PMC] [Abstract]

"Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis."
Am. J. Hum. Genet. 54:179-190(1994) [PubMed] [Europe PMC] [Abstract]

"Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity."
J. Clin. Invest. 93:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]

"Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)."
J. Invest. Dermatol. 102:24-30(1994) [PubMed] [Europe PMC] [Abstract]

"Genetic and clinical mosaicism in a type of epidermal nevus."
N. Engl. J. Med. 331:1408-1415(1994) [PubMed] [Europe PMC] [Abstract]

"A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma."
J. Invest. Dermatol. 108:357-361(1997) [PubMed] [Europe PMC] [Abstract]

"A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma."
J. Invest. Dermatol. 111:1220-1223(1998) [PubMed] [Europe PMC] [Abstract]

"A novel substitution in keratin 10 in epidermolytic hyperkeratosis."
J. Invest. Dermatol. 112:506-508(1999) [PubMed] [Europe PMC] [Abstract]

"Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis."
Br. J. Dermatol. 164:442-447(2011) [PubMed] [Europe PMC] [Abstract]