Angiopoietin Like Protein 3 (ANGPTL3)
ANGPT5; ANG-5; Angiopoietin 5; Angiopoietin-related protein 3
Angiopoietin-like protein 3 (ANGPTL3) is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of LPL and EL, and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Hu01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Hu01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Hu01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Hu01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Hu01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Mu01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Mu01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Mu01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Mu01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Mu01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Ra01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Ra01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Ra01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Ra01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Ra01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Ca01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Ca01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Ca01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Ca01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Ca01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Po01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Po01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Po01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Po01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Po01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Bo01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Bo01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Bo01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Bo01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Bo01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Rb01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Rb01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Rb01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Rb01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Rb01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV140Mo01 | Recombinant Angiopoietin Like Protein 3 (ANGPTL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV140Mo01 | Monoclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IP. |
| PAV140Mo01 | Polyclonal Antibody to Angiopoietin Like Protein 3 (ANGPTL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV140Mo01 | CLIA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | CLIA assay for Antigen Detection |
| ELV140Mo01 | ELISA Kit for Angiopoietin Like Protein 3 (ANGPTL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia."
N. Engl. J. Med. 363:2220-2227(2010) [PubMed] [Europe PMC] [Abstract]
"Atypical angiopoietin-like protein that regulates ANGPTL3."
Proc. Natl. Acad. Sci. U.S.A. 109:19751-19756(2012) [PubMed] [Europe PMC] [Abstract]
"Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels."
Hum. Mutat. 33:448-455(2012) [PubMed] [Europe PMC] [Abstract]