Lipocalin 1 (LCN1)

TP; PMFA; VEGP; Tlc; Tear Prealbumin; Tear lipocalin; Protein Migrating Faster Than Albumin; Von Ebner Gland Protein

SPN	V133
HGNC	6525
MGI	102669
PubMed	11850445
RGD	1562745
UniProt	P31025
Wiki	LCN1

Lipocalin-1 belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. This protein may bind hydrophobic ligands and inhibit cysteine proteinases. It may also play a role in taste reception.

Based on the known 3-dimensional structure of 5 members of the lipocalin family, i.e., retinol binding protein , beta-lactoglobulin, bilin binding protein, mouse major urinary protein, and rat urinary alpha-2-globulin, the general architecture appears to be highly appropriate for binding a variety of hydrophobic ligands. On the basis of highly conserved amino acid sequences and of a size around 18 to 20 kD, about 20 proteins have been designated as lipocalins.

Reference

"Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands."
Biochim. Biophys. Acta 1172:131-137(1993) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily."
J. Biol. Chem. 267:20282-20287(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human lacrimal lipocalin secreted in tears."
Exp. Eye Res. 56:605-609(1993) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli."
Gene 139:177-183(1994) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of a lipocalin in human nasal mucosa."
Comp. Biochem. Physiol. 118B:819-824(1997)

"Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display."
J. Biol. Chem. 276:20206-20212(2001) [PubMed] [Europe PMC] [Abstract]

"Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells."
J. Biol. Chem. 278:16209-16215(2003) [PubMed] [Europe PMC] [Abstract]

"The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands."
J. Biol. Chem. 280:484-493(2005) [PubMed] [Europe PMC] [Abstract]