Myeloid Differentiation Factor 88 (MyD88)
Myeloid Differentiation Primary Response Gene 88
Myeloid differentiation factor 88 (MyD88) is a key adaptor protein that MyD88 is a common adaptor molecule required for signaling mediated by TLRs. When the receptors are activated, cells bearing TLRs produce various proinflammatory cytokines in a MyD88-dependent manner. Liver regeneration following partial hepatectomy (PH) requires innate immune responses, particularly interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production by Kupffer cells, although the recognition and activation processes are still unknown. However, TLR2, 4 and 9, which recognize gram-negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88-mediated pathways.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Hu01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Hu01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Hu01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Hu01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Hu01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Mu01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Mu01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Mu01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Mu01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Mu01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Ra01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Ra01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Ra01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Ra01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Ra01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Ca01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Ca01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Ca01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Ca01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Ca01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Po01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Po01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Po01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Po01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Po01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Bo01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Bo01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Bo01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Bo01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Bo01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Rb01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Rb01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Rb01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Rb01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Rb01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV132Mo01 | Recombinant Myeloid Differentiation Factor 88 (MyD88) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV132Mo01 | Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IP. |
| PAV132Mo01 | Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV132Mo01 | CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) | CLIA assay for Antigen Detection |
| ELV132Mo01 | ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular characterization and modular analysis of human MyD88."
Oncogene 13:2467-2475(1996) [PubMed] [Europe PMC] [Abstract]
"The cloning and characterization of human MyD88: a member of an IL-1 receptor related family."
FEBS Lett. 402:81-84(1997) [PubMed] [Europe PMC] [Abstract]
"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6."
Nat. Immunol. 5:1061-1068(2004) [PubMed] [Europe PMC] [Abstract]
"Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling."
Proc. Natl. Acad. Sci. U.S.A. 101:15416-15421(2004) [PubMed] [Europe PMC] [Abstract]
"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Nat. Immunol. 7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]
"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
J. Immunol. 180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]
"Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins."
J. Immunol. 182:3450-3460(2009) [PubMed] [Europe PMC] [Abstract]
"AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."
J. Biol. Chem. 285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]
"Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly."
J. Biol. Chem. 286:1341-1353(2011) [PubMed] [Europe PMC] [Abstract]
"Oncogenically active MYD88 mutations in human lymphoma."
Nature 470:115-119(2011) [PubMed] [Europe PMC] [Abstract]
"IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."
Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
"Functional assessment of the mutational effects of human IRAK4 and MyD88 genes."
Mol. Immunol. 58:66-76(2014) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling."
Proc. Natl. Acad. Sci. U.S.A. 106:10260-10265(2009) [PubMed] [Europe PMC] [Abstract]
"Solution NMR structure of human myeloid differentiation primary response (MYD88)."
Submitted (FEB-2009) to the PDB data bank
"Pyogenic bacterial infections in humans with MyD88 deficiency."
Science 321:691-696(2008) [PubMed] [Europe PMC] [Abstract]
"Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency."
Medicine (Baltimore) 89:403-425(2010) [PubMed] [Europe PMC] [Abstract]
"MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia."
N. Engl. J. Med. 367:826-833(2012) [PubMed] [Europe PMC] [Abstract]