T-Cell Leukemia/Lymphoma Protein 1A (TCL1A)
Tgtp; TCL1A; TCL1; T-Cell Specific GTPase; Oncogene TCL1; Protein p14 TCL1
TCL1, is situated at 14q32.3 and is activated when it comes into juxtaposition with the TCRA locus with inversion . Erikson et al. showed that the TCRA locus is split between the proximal V gene and the more distal C gene by the breakpoint at 14q11.2 that creates of T-cell leukemia. Mathieu-Mahul et al.cloned a DNA fragment from 14q11 in a case of T-cell malignancy. Mengle-Gaw et al. and Davey et al. both studied chromosome rearrangements, inversions, or translocations, involving 14q in patients with ataxia-telangiectasia . These patients are prone to the development of lymphatic neoplasms in association with these abnormalities. Mengle-Gaw et al. concluded that a single locus at chromosome band 14q32.1, located about 15-20 million basepairs centromeric to the IGH locus, is critical to the development of neoplasia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Hu01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Hu01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Hu01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Hu01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Hu01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Mu01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Mu01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Mu01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Mu01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Mu01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Ra01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Ra01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Ra01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Ra01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Ra01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Ca01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Ca01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Ca01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Ca01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Ca01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Po01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Po01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Po01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Po01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Po01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Bo01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Bo01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Bo01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Bo01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Bo01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Rb01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Rb01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Rb01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Rb01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Rb01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV130Mo01 | Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV130Mo01 | Monoclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IP. |
| PAV130Mo01 | Polyclonal Antibody to T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV130Mo01 | CLIA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | CLIA assay for Antigen Detection |
| ELV130Mo01 | ELISA Kit for T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of the TCL1 gene involved in T-cell malignancies."
Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization and localization of the TCL-1 oncogene product."
Cancer Res. 54:6297-6301(1994) [PubMed] [Europe PMC] [Abstract]
"The protooncogene TCL1 is an Akt kinase coactivator."
Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation."
Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000) [PubMed] [Europe PMC] [Abstract]
"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1."
Mol. Cell. Biol. 22:1513-1525(2002) [PubMed] [Europe PMC] [Abstract]
"The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity."
Cancer Lett. 248:198-210(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology."
Structure 6:147-155(1998) [PubMed] [Europe PMC] [Abstract]