Kruppel Like Factor 5, Intestinal (KLF5)

KLF5; BTEB2; CKLF; IKLF; Intestinal Enriched Krüppel-Like Factor; Colon krueppel-like factor; Basic Transcription Element Binding Protein 2; GC-box-binding protein 2

SPN	V127
HGNC	6349
MGI	1338056
PubMed	16054042
RGD	621446
UniProt	Q13887
Wiki	KLF5

• Krueppel-like factor 5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

• Klf5, also known as (IKLF) or  (Bteb2) has been assigned purely transcriptional activation activity (Fig. 1A) but, similar to Klf4, binds p300 which acetylates the first zinc finger conferring a trans-activating function. Importantly for Klf4 & Klf5, the amino acids that are predicted by the Klevit model to interact with DNA are identical (Fig. 1B and Fig. 2) and the two compete for the same CACCC element found in a wide variety of promoters.

Reference

"Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter."
Nucleic Acids Res. 27:4807-4815(1999) [PubMed] [Europe PMC] [Abstract]

"Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2."
Nucleic Acids Res. 21:1527-1532(1993) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."
Oncogene 24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5."
Submitted (FEB-2008) to the PDB data bank

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]