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Kell Protein (KEL)

CD238; ECE3; Kell Blood Group,Metalloendopeptidase; Metallo-Endopeptidase; Kell blood group glycoprotein

SPN V124
HGNC 6308
MGI 1346053
PubMed 7949106
RGD 1565470
UniProt P23276
Wiki KEL

  • The KEL gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.

  • The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. There are several alleles of the gene which creates Kell protein. Two such alleles, K1 (Kell) and K2 (Cellano), are the most common. The kell protein is tightly bound to a second protein, XK, by a disulfide bond. Absence of the XK protein (such as through genetic deletion), leads to marked reduction of the Kell antigens on the red blood cell surface. Absence of the Kell protein (K0), however, does not affect the XK protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V124Hu01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
PV124Hu01 Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V124Mu01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
PV124Mu01 Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V124Ra01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
PV124Ra01 Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kell Protein (KEL) Bioactivity
Antibodies NONE Monoclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kell Protein (KEL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kell Protein (KEL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kell Protein (KEL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kell Protein (KEL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kell Protein (KEL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kell Protein (KEL) CLIA assay for Antigen Detection

Reference

"Molecular cloning and primary structure of Kell blood group protein."
Proc. Natl. Acad. Sci. U.S.A. 88:6353-6357(1991) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene encoding the human Kell blood group protein."
Blood 85:1364-1370(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of the K:6,-7 [Js(a+b-)] phenotype in the Kell blood group system."
Transfusion 35:822-825(1995) [PubMed] [Europe PMC] [Abstract]

"Association of XK and Kell blood group proteins."
J. Biol. Chem. 273:13950-13956(1998) [PubMed] [Europe PMC] [Abstract]

"Proteolytic processing of big endothelin-3 by the kell blood group protein."
Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]

"Expression of Kell blood group protein in nonerythroid tissues."
Blood 96:340-346(2000) [PubMed] [Europe PMC] [Abstract]

"Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells."
Biochem. J. 356:171-180(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of the Kell (K1) phenotype."
Blood 85:912-916(1995) [PubMed] [Europe PMC] [Abstract]

"Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles."
Transfusion 36:490-494(1996) [PubMed] [Europe PMC] [Abstract]

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