Protein Kinase B Beta (PKBb)
AKT2; PKBBETA; PRKB-B; RAC-BETA; RAC-Beta Serine/Threonine-Protein Kinase; V-Akt Murine Thymoma Viral Oncogene Homolog 2
AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phosphorylating several known proteins. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initaited by the large T antigen as well as the neu oncogene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V120Hu01 | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | MV120Hu22 | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| PV120Hu01 | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV120Hu | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V120Ra01 | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | MV120Ra21 | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| PV120Ra01 | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV120Ra | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Protein Kinase B Beta (PKBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Protein Kinase B Beta (PKBb) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Protein Kinase B Beta (PKBb) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Protein Kinase B Beta (PKBb) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Protein Kinase B Beta (PKBb) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Protein Kinase B Beta (PKBb) | CLIA assay for Antigen Detection |
Reference
"Molecular cloning of a second form of rac protein kinase."
Cell Regul. 2:1001-1009(1991) [PubMed] [Europe PMC] [Abstract]
"AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas."
Proc. Natl. Acad. Sci. U.S.A. 89:9267-9271(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha."
Biochem. J. 331:299-308(1998) [PubMed] [Europe PMC] [Abstract]
"The protooncogene TCL1 is an Akt kinase coactivator."
Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
"Activation of a GST-tagged AKT2/PKBbeta."
Biochim. Biophys. Acta 1725:340-347(2005) [PubMed] [Europe PMC] [Abstract]
"Kinetic mechanism of AKT/PKB enzyme family."
J. Biol. Chem. 281:13949-13956(2006) [PubMed] [Europe PMC] [Abstract]
"Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA."
J. Cell. Physiol. 214:158-165(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt."
Dev. Cell 17:800-810(2009) [PubMed] [Europe PMC] [Abstract]
"ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization."
Mol. Cell. Biol. 29:1459-1471(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"The E3 ligase TRAF6 regulates Akt ubiquitination and activation."
Science 325:1134-1138(2009) [PubMed] [Europe PMC] [Abstract]
"Akt2 and Akt3 play a pivotal role in malignant gliomas."
Neuro-oncol. 12:221-232(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Akt signalling in health and disease."
Cell. Signal. 23:1515-1527(2011) [PubMed] [Europe PMC] [Abstract]
"Akt1 and Akt2: differentiating the aktion."
Histol. Histopathol. 26:651-662(2011) [PubMed] [Europe PMC] [Abstract]
"Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2)."
Mol. Biol. Cell 22:2946-2956(2011) [PubMed] [Europe PMC] [Abstract]
"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation."
Mol. Cell 9:1227-1240(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP."
Nat. Struct. Biol. 9:940-944(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of an inactive Akt2 kinase domain."
Structure 11:21-30(2003) [PubMed] [Europe PMC] [Abstract]
"Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates."
J. Biomol. NMR 28:137-155(2004) [PubMed] [Europe PMC] [Abstract]
"A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera."
J. Mol. Biol. 367:882-894(2007) [PubMed] [Europe PMC] [Abstract]
"Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase."
J. Med. Chem. 51:5663-5679(2008) [PubMed] [Europe PMC] [Abstract]
"Aminofurazans as potent inhibitors of AKT kinase."
Bioorg. Med. Chem. Lett. 19:1508-1511(2009) [PubMed] [Europe PMC] [Abstract]
"A family with severe insulin resistance and diabetes due to a mutation in AKT2."
Science 304:1325-1328(2004) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis."
J. Clin. Invest. 119:315-322(2009) [PubMed] [Europe PMC] [Abstract]
"An activating mutation of AKT2 and human hypoglycemia."
Science 334:474-474(2011) [PubMed] [Europe PMC] [Abstract]