Serum/Glucocorticoid Regulated Kinase 1 (SGK1)

Serine/threonine-protein kinase Sgk1

SPN	V119
HGNC	10810
MGI	1340062
PubMed	16982696
RGD	3668
UniProt	O00141
Wiki	SGK1

Sgk1 is  a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by TGF-beta which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition.

Reference

"Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume."
Proc. Natl. Acad. Sci. U.S.A. 94:4440-4445(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and chromosomal localization of the human SGK protein kinase gene."
Genomics 51:299-302(1998) [PubMed] [Europe PMC] [Abstract]

"An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function."
Am. J. Physiol. 295:F1440-F1448(2008) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase."
Biochem. J. 344:189-197(1999) [PubMed] [Europe PMC] [Abstract]

"Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2."
Biochem. J. 339:319-328(1999) [PubMed] [Europe PMC] [Abstract]

"Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy."
Proc. Natl. Acad. Sci. U.S.A. 97:8157-8162(2000) [PubMed] [Europe PMC] [Abstract]

"BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase."
J. Biol. Chem. 276:8631-8634(2001) [PubMed] [Europe PMC] [Abstract]

"Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin."
J. Biol. Chem. 276:9406-9412(2001) [PubMed] [Europe PMC] [Abstract]

"Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf."
J. Biol. Chem. 276:31620-31626(2001) [PubMed] [Europe PMC] [Abstract]

"Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)."
Mol. Cell. Biol. 21:952-965(2001) [PubMed] [Europe PMC] [Abstract]

"Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel."
J. Biol. Chem. 277:5-8(2002) [PubMed] [Europe PMC] [Abstract]

"Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."
Kidney Blood Press. Res. 25:370-374(2002) [PubMed] [Europe PMC] [Abstract]

"K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."
Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1."
Biochem. Biophys. Res. Commun. 311:629-634(2003) [PubMed] [Europe PMC] [Abstract]

"Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A."
Cardiovasc. Res. 57:1079-1084(2003) [PubMed] [Europe PMC] [Abstract]

"Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1."
J. Biochem. 133:103-108(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B."
J. Neurochem. 86:1181-1188(2003) [PubMed] [Europe PMC] [Abstract]

"Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain."
Mol. Biol. Cell 14:1221-1239(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."
Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1."
Am. J. Physiol. 287:G143-G150(2004) [PubMed] [Europe PMC] [Abstract]

"Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B."
Biochem. Biophys. Res. Commun. 313:998-1003(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes."
Cell. Physiol. Biochem. 14:203-212(2004) [PubMed] [Europe PMC] [Abstract]

"A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit."
J. Biol. Chem. 279:38134-38142(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."
J. Cell. Physiol. 199:194-199(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases."
Kidney Int. 66:1918-1925(2004) [PubMed] [Europe PMC] [Abstract]

"Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1."
Am. J. Physiol. 289:C802-C810(2005) [PubMed] [Europe PMC] [Abstract]

"The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2."
Biochem. Biophys. Res. Commun. 331:272-277(2005) [PubMed] [Europe PMC] [Abstract]

"Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3."
Biochem. Biophys. Res. Commun. 329:738-742(2005) [PubMed] [Europe PMC] [Abstract]

"Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3."
Biochem. Biophys. Res. Commun. 334:742-746(2005) [PubMed] [Europe PMC] [Abstract]

"Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB."
FEBS Lett. 579:1534-1538(2005) [PubMed] [Europe PMC] [Abstract]

"Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation."
J. Biol. Chem. 280:4518-4523(2005) [PubMed] [Europe PMC] [Abstract]

"SGK1 kinase upregulates GLUT1 activity and plasma membrane expression."
Diabetes 55:421-427(2006) [PubMed] [Europe PMC] [Abstract]

"Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau."
Mol. Cell. Biol. 26:8357-8370(2006) [PubMed] [Europe PMC] [Abstract]

"Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells."
Am. J. Physiol. 292:C1971-C1981(2007) [PubMed] [Europe PMC] [Abstract]

"Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4."
Biochem. Biophys. Res. Commun. 356:629-635(2007) [PubMed] [Europe PMC] [Abstract]

"Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3."
FEBS Lett. 581:5586-5590(2007) [PubMed] [Europe PMC] [Abstract]

"Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue."
BMB Rep. 41:41-47(2008) [PubMed] [Europe PMC] [Abstract]

"mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)."
Biochem. J. 416:375-385(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons."
Proc. Natl. Acad. Sci. U.S.A. 105:4459-4464(2008) [PubMed] [Europe PMC] [Abstract]

"Regulation of a third conserved phosphorylation site in SGK1."
J. Biol. Chem. 284:3453-3460(2009) [PubMed] [Europe PMC] [Abstract]

"Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
J. Hepatol. 51:67-76(2009) [PubMed] [Europe PMC] [Abstract]

"Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation."
J. Mol. Med. 87:1221-1239(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."
Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]

"mTOR complex-2 activates ENaC by phosphorylating SGK1."
J. Am. Soc. Nephrol. 21:811-818(2010) [PubMed] [Europe PMC] [Abstract]

"Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation."
PLoS ONE 5:E12163-E12163(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."
Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]

"Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity."
Cell. Physiol. Biochem. 13:1-12(2003) [PubMed] [Europe PMC] [Abstract]

"Sgk kinases and their role in epithelial transport."
Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]

"Second AKT: the rise of SGK in cancer signalling."
Growth Factors 28:394-408(2010) [PubMed] [Europe PMC] [Abstract]

"Significance of SGK1 in the regulation of neuronal function."
J. Physiol. (Lond.) 588:3349-3354(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP."
Protein Sci. 16:2761-2769(2007) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]