B And T-Lymphocyte Attenuator (BTLA)
CD272; BTLA1; B-and T-lymphocyte-associated protein
BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4 , BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family (TNF) receptors, not just the B7 family of cell surface receptors.
BTLA is a ligand for tumour necrosis factor (ligand) superfamily, member 14 (TNFSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.Northern blot analysis revealed expression in lymph node and spleen, as well as in polarized Th1 but not Th2 cells. Flow cytometric analysis demonstrated surface expression of a transmembrane protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Hu01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Hu01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Hu01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Hu01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Hu01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Mu01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Mu01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Mu01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Mu01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Mu01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Ra01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Ra01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Ra01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Ra01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Ra01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Ca01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Ca01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Ca01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Ca01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Ca01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Po01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Po01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Po01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Po01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Po01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Bo01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Bo01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Bo01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Bo01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Bo01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Rb01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Rb01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Rb01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Rb01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Rb01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV116Mo01 | Recombinant B And T-Lymphocyte Attenuator (BTLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV116Mo01 | Monoclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IP. |
| PAV116Mo01 | Polyclonal Antibody to B And T-Lymphocyte Attenuator (BTLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV116Mo01 | CLIA Kit for B And T-Lymphocyte Attenuator (BTLA) | CLIA assay for Antigen Detection |
| ELV116Mo01 | ELISA Kit for B And T-Lymphocyte Attenuator (BTLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1."
Nat. Immunol. 4:670-679(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2."
Biochem. Biophys. Res. Commun. 312:1236-1243(2003) [PubMed] [Europe PMC] [Abstract]
"B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator."
Nat. Immunol. 6:90-98(2005) [PubMed] [Europe PMC] [Abstract]
"Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex."
J. Biol. Chem. 280:39553-39561(2005) [PubMed] [Europe PMC] [Abstract]