Pyridoxal Kinase (PDXK)

PKH; PNK; C21orf124; C21orf97; PRED79; Pyridoxine Kinase; Vitamin B6 Kinase

SPN	V115
HGNC	8819
MGI	1351869
PubMed	16740960
RGD	621324
UniProt	O00764
Wiki	PDXK

Pyridoxal (pyridoxine, vitamin B6) kinase is also known as PDXK. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Hanna et al. (1997) cloned the cDNA encoding PDXK, which they referred to as PKH. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA revealed pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript was expressed in all tissues tested.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	PV115Hu01	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	V115Mu01	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	PV115Mu01	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	PV115Ra01	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Pyridoxal Kinase (PDXK)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Pyridoxal Kinase (PDXK)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Pyridoxal Kinase (PDXK)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Pyridoxal Kinase (PDXK)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Pyridoxal Kinase (PDXK)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Pyridoxal Kinase (PDXK)	CLIA assay for Antigen Detection

Reference

"Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor."
J. Biol. Chem. 272:10756-10760(1997) [PubMed] [Europe PMC] [Abstract]

"Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis."
Asian J. Androl. 6:83-91(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human pyridoxal kinase: overexpression and properties of the recombinant enzyme."
Mol. Cells 10:452-459(2000) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]