Natural Killer Cell Receptor 2B4 (NKR2B4)
CD244; 2B4; NAIL; NKR2-B4; Nmrk; SLAMF4; NK cell activation-inducing ligand; Signaling lymphocytic activation molecule 4
2B4, called also NKR2B4 [natural killer cell receptor 2B4] has been identified originally on mouse NK-cells and subsets of T-cells mediating nonMHC restricted cell killing. Murine NK-cells express two alternatively spliced isoforms, designated 2B4-S and 2B4-L. 2B4-S functions as an activating receptor, whereas 2B4-L is inhibitory. The new designation of this protein is CD244.
The 2B4 protein is expressed on all NK-cells, a subset of CD8(+) T-cells, basophils, mast cells, and monocytes. 2B4 is considered to be an activating receptor because cross-linking of 2B4 on NK-cells with a monoclonal antibody leads to NK-cell activation in vitro. However, 2B4 can also act as an inhibitory signaling receptor for NK-cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Hu01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Hu01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Hu01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Hu01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Hu01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Mu01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Mu01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Mu01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Mu01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Mu01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Ra01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Ra01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Ra01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Ra01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Ra01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Ca01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Ca01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Ca01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Ca01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Ca01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Po01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Po01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Po01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Po01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Po01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Bo01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Bo01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Bo01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Bo01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Bo01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Rb01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Rb01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Rb01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Rb01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Rb01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV114Mo01 | Recombinant Natural Killer Cell Receptor 2B4 (NKR2B4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV114Mo01 | Monoclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IP. |
| PAV114Mo01 | Polyclonal Antibody to Natural Killer Cell Receptor 2B4 (NKR2B4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV114Mo01 | CLIA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | CLIA assay for Antigen Detection |
| ELV114Mo01 | ELISA Kit for Natural Killer Cell Receptor 2B4 (NKR2B4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Activating interactions in human NK cell recognition: the role of 2B4-CD48."
Eur. J. Immunol. 29:1676-1683(1999) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48."
Eur. J. Immunol. 29:3466-3477(1999) [PubMed] [Europe PMC] [Abstract]
"Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP."
J. Immunol. 162:6981-6985(1999) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4."
Tissue Antigens 54:27-34(1999) [PubMed] [Europe PMC] [Abstract]
"Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript."
Immunogenetics 51:987-992(2000) [PubMed] [Europe PMC] [Abstract]
"X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells."
J. Exp. Med. 192:337-346(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Functional role of human NK cell receptor 2B4 (CD244) isoforms."
Eur. J. Immunol. 39:1632-1641(2009) [PubMed] [Europe PMC] [Abstract]
"Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein."
J. Biol. Chem. 286:24142-24149(2011) [PubMed] [Europe PMC] [Abstract]