B-Cell CLL/Lymphoma 3 (Bcl3)

BCL3; BCL4; B-Cell Lymphoma 3-Encoded Protein; B-Cell Lymphoma 3-Encoded Protein; Chronic Lymphatic Leukemia Protein; Proto-oncogene BCL3

SPN	V105
HGNC	998
MGI	88140
PubMed	8196632
RGD	1589465
UniProt	P20749
Wiki	BCL3

B-cell lymphoma 3-encoded protein is  a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins.

This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.Wulczyn et al. (1992) and Franzoso et al. (1992) found that the BCL3 gene encodes an inhibitor (antagonist) for subunit 2 of nuclear factor kappa-B (NFKB2).

Reference

"The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control."
Cell 60:991-997(1990) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the candidate proto-oncogene BCL3."
Genomics 24:120-126(1994) [PubMed] [Europe PMC] [Abstract]

"The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers."
Cell 72:729-739(1993) [PubMed] [Europe PMC] [Abstract]

"NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes."
EMBO J. 18:4766-4778(1999) [PubMed] [Europe PMC] [Abstract]

"The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators."
Oncogene 18:3316-3323(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination."
J. Biol. Chem. 278:26102-26110(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family."
EMBO J. 20:6180-6190(2001) [PubMed] [Europe PMC] [Abstract]

"GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity."
Mol. Cell 16:35-45(2004) [PubMed] [Europe PMC] [Abstract]