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Caspase 4 (CASP4)

ICE(rel)II; ICH2; TX; Protease ICH-2; Cysteinyl Aspartate Specific Proteinases 4; Apoptosis-Related Cysteine Peptidase

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5, with a role in the immune system.

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Hu01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Hu01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Hu01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Hu01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Hu01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Mu01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Mu01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Mu01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Mu01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Mu01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Ra01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Ra01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Ra01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Ra01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Ra01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Ca01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Ca01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Ca01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Ca01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Ca01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Po01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Po01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Po01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Po01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Po01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Bo01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Bo01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Bo01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Bo01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Bo01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Rb01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Rb01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Rb01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Rb01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Rb01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV104Mo01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV104Mo01 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAV104Mo01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits CLV104Mo01 CLIA Kit for Caspase 4 (CASP4) CLIA assay for Antigen Detection
ELV104Mo01 ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells."
EMBO J. 14:1914-1922(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases."
J. Biol. Chem. 270:15870-15876(1995) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases."
J. Biol. Chem. 270:15250-15256(1995) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death."
J. Cell Biol. 165:347-356(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis."
J. Biol. Chem. 288:17908-17917(2013) [PubMed] [Europe PMC] [Abstract]

"The E.coli effector protein NleF is a caspase inhibitor."
PLoS ONE 0:0-0(2013)