C-Type Lectin Domain Family 4, Member C (CLEC4C)

CD303; CLECSF11,CLECSF7; HECL; DLEC; BDCA2; Blood dendritic cell antigen 2; C-type lectin superfamily member 7; Dendritic lectin

SPN	V098
HGNC	13258
MGI	3588267
PubMed	21880719
UniProt	Q8WTT0
Wiki	CLEC4C

CLEC4C is a dendritic cell marker.By searching for sequences similar to mouse Nkcl, Fernandes et al. (2000) identified an EST clone isolated from a testis cDNA library that contained the full-length coding sequence for CLECSF11, which they designated HECL. The deduced 183-amino acid protein has a calculated molecular mass of 20 kD and contains a C-type carbohydrate recognition domain (CRD) and 3 putative N-glycosylation sites, but no transmembrane domain or signal peptide. HECL shares significant homology with members of the C-type lectin superfamily, and its CRD is mose similar to that of mouse Nkcl. The 4 cysteines responsible for the C-type CRD fold are perfectly conserved between HECL and mouse Nkcl. Immunolocalization of epitope-tagged HECL expressed in COS cells revealed a cytoplasmic localization.

Reference

"Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells."
Eur. J. Immunol. 31:2733-2740(2001) [PubMed] [Europe PMC] [Abstract]

"BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction."
J. Exp. Med. 194:1823-1834(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12."
Genomics 69:263-270(2000) [PubMed] [Europe PMC] [Abstract]