Signal Transducer And Activator Of Transcription 3 (STAT3)
APRF; Acute-Phase Response Factor
STAT3, a transcription factor for acute phase response genes, acts as an adaptor molecule in signal transduction from the type I interferon receptor. They found that it binds to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and undergoes interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, was found to bind to phosphorylated STAT3 and subsequently to undergo tyrosine phosphorylation. The authors concluded that STAT3 acts as an adaptor to couple another signaling pathway to the interferon receptor.In many human cancers and transformed cell lines, STAT3 is persistently activated, and in cell culture, active STAT3 is either required for transformation, enhances transformation, or blocks apoptosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Hu01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Hu01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Hu01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Hu01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Hu01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Mu01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Mu01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Mu01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Mu01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Mu01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Ra01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Ra01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Ra01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Ra01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Ra01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Ca01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Ca01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Ca01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Ca01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Ca01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Po01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Po01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Po01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Po01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Po01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Bo01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Bo01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Bo01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Bo01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Bo01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Rb01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Rb01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Rb01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Rb01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Rb01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV096Mo01 | Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV096Mo01 | Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IP. |
| PAV096Mo01 | Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV096Mo01 | CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | CLIA assay for Antigen Detection |
| ELV096Mo01 | ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
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