Ubiquitin D (UBD)
UB-D; FAT10; UBD-3; Diubiquitin; Ubiquitin-like protein FAT10
Ubiquitin D is a protein encoded by the UBD gene.Using selective cDNA hybridization of a YAC containing the HLA-F locus region on chromosome 6, followed by Southern and Northern blot analyses, Fan et al. (1996) isolated a cDNA, which they called 1F12, encoding a protein similar to diubiquitin. The 1.1-kb transcript was detected only in B-cell lines transformed by Epstein-Barr virus.
By subtractive hybridization of dendritic cell (DC) libraries and EST database searching, Bates et al. (1997) obtained a full-length cDNA encoding diubiquitin. The predicted 165-amino acid protein has 2 ubiquitin-like domains, each of which has 2 cysteines. Southern blot analysis indicated that the cDNA represents a single-copy gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Hu01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Hu01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Hu01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Hu01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Hu01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Mu01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Mu01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Mu01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Mu01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Mu01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Ra01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Ra01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Ra01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Ra01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Ra01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Ca01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Ca01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Ca01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Ca01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Ca01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Po01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Po01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Po01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Po01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Po01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Bo01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Bo01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Bo01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Bo01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Bo01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Rb01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Rb01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Rb01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Rb01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Rb01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV095Mo01 | Recombinant Ubiquitin D (UBD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV095Mo01 | Monoclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IP. |
| PAV095Mo01 | Polyclonal Antibody to Ubiquitin D (UBD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV095Mo01 | CLIA Kit for Ubiquitin D (UBD) | CLIA assay for Antigen Detection |
| ELV095Mo01 | ELISA Kit for Ubiquitin D (UBD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells."
Eur. J. Immunol. 27:2471-2477(1997) [PubMed] [Europe PMC] [Abstract]
"A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2."
Proc. Natl. Acad. Sci. U.S.A. 96:4313-4318(1999) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers."
Oncogene 22:2592-2603(2003) [PubMed] [Europe PMC] [Abstract]
"NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation."
J. Biol. Chem. 279:16503-16510(2004) [PubMed] [Europe PMC] [Abstract]
"FAT10, a ubiquitin-independent signal for proteasomal degradation."
Mol. Cell. Biol. 25:3483-3491(2005) [PubMed] [Europe PMC] [Abstract]
"FAT10, a gene up-regulated in various cancers, is cell-cycle regulated."
Cell Div. 1:20-20(2006) [PubMed] [Europe PMC] [Abstract]
"Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease."
J. Am. Soc. Nephrol. 17:996-1004(2006) [PubMed] [Europe PMC] [Abstract]
"FAT10 plays a role in the regulation of chromosomal stability."
J. Biol. Chem. 281:11413-11421(2006) [PubMed] [Europe PMC] [Abstract]
"The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10."
J. Biol. Chem. 281:20045-20054(2006) [PubMed] [Europe PMC] [Abstract]
"p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers."
Oncogene 25:2318-2327(2006) [PubMed] [Europe PMC] [Abstract]
"E1-L2 activates both ubiquitin and FAT10."
Mol. Cell 27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]
"The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."
J. Cell Sci. 121:4079-4088(2008) [PubMed] [Europe PMC] [Abstract]
"Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon."
Oncogene 27:6068-6074(2008) [PubMed] [Europe PMC] [Abstract]
"Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L."
FEBS Lett. 583:591-594(2009) [PubMed] [Europe PMC] [Abstract]
"Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system."
Int. J. Biochem. Cell Biol. 41:1205-1215(2009) [PubMed] [Europe PMC] [Abstract]
"FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy."
J. Virol. 83:11983-11988(2009) [PubMed] [Europe PMC] [Abstract]
"FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging."
World J. Gastroenterol. 15:2228-2233(2009) [PubMed] [Europe PMC] [Abstract]
"The ubiquitin-like protein FAT10 mediates NF-kappa-B activation."
J. Am. Soc. Nephrol. 21:316-326(2010) [PubMed] [Europe PMC] [Abstract]