Tryptophanyl tRNA Synthetase (WARS)

GAMMA-2; IFI53; IFP53; WRS; TrpRS; hWRS; Tryptophan tRNA Ligase 1,Cytoplasmic; Interferon-induced protein 53; Tryptophanyl-tRNA synthetase

SPN	V091
HGNC	12729
MGI	104630
PubMed	16798914
RGD	1308278
UniProt	P23381
Wiki	WARS_(gene

Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene,Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.

Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family.

Reference

"Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts."
J. Biol. Chem. 266:24245-24248(1991) [PubMed] [Europe PMC] [Abstract]

"Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase."
Proc. Natl. Acad. Sci. U.S.A. 88:11520-11524(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning and nucleotide sequence of the structural gene encoding for human tryptophanyl-tRNA synthetase."
Gene 109:291-296(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor."
EMBO J. 11:489-496(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of 5'-terminal exons of the human tryptophanyl-tRNA synthetase gene."
Mol. Biol. (Mosk.) 30:319-329(1996) [PubMed] [Europe PMC] [Abstract]

"The human gene encoding tryptophanyl-tRNA synthetase: interferon-response elements and exon-intron organization."
Gene 128:237-245(1993) [PubMed] [Europe PMC] [Abstract]

"Gamma interferon potently induces tryptophanyl-tRNA synthetase expression in human keratinocytes."
J. Invest. Dermatol. 100:775-779(1993) [PubMed] [Europe PMC] [Abstract]