SHC-Transforming Protein 2 (SHC2)

SCK; SHCB; SLI; Src Homology 2 Domain Containing Transforming Protein 2; SH2 domain protein C2

SPN	V088
HGNC	29869
MGI	106180
PubMed	21658278
RGD	1307137
UniProt	P98077
Wiki	SHC2

• Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins involved in growth factor and cytokine receptor signaling. The PTB domain of SHC1 specifically binds to the tyrosine-phosphorylated, 145-kD protein INPP5D.

• By screening placental and hepatoma cDNA libraries using an EST encoding a putative PTB domain-containing protein as probe, Kavanaugh and Williams (1994) identified a partial cDNA encoding SCK (SHC-like). They determined that the SCK protein contains both a PTB and an SH2 domain.

• Northern blot analysis indicated that unlike SHC1, which is ubiquitously expressed with very low expression in brain, SCK is expressed higher in liver than in other tissues and is expressed in brain.

Reference

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]

"A family of Shc related proteins with conserved PTB, CH1 and SH2 regions."
Oncogene 13:633-641(1996) [PubMed] [Europe PMC] [Abstract]

"An alternative to SH2 domains for binding tyrosine-phosphorylated proteins."
Science 266:1862-1865(1994) [PubMed] [Europe PMC] [Abstract]

"ShcB and ShcC activation by the Trk family of receptor tyrosine kinases."
J. Biol. Chem. 277:26046-26056(2002) [PubMed] [Europe PMC] [Abstract]

"Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation."
J. Biol. Chem. 280:24680-24689(2005) [PubMed] [Europe PMC] [Abstract]