Major Histocompatibility Complex Class I E (MHCE)
HLAE; EA1.2; EA2.1; HLA-6.2; MHC-E; HLA-E; Leukocyte Antigen E; MHC class I antigen E; HLA class I histocompatibility antigen, alpha chain E
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. HLA-E is a protein that is a member of the HLA family. It is one of a family of molecules known as MHC class Ib and has a very specialized role in cell recognition by NK cells (Natural Killer).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Hu01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Hu01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Hu01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Hu01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Hu01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Mu01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Mu01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Mu01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Mu01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Mu01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Ra01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Ra01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Ra01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Ra01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Ra01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Ca01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Ca01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Ca01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Ca01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Ca01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Po01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Po01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Po01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Po01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Po01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Bo01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Bo01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Bo01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Bo01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Bo01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Rb01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Rb01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Rb01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Rb01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Rb01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV087Mo01 | Recombinant Major Histocompatibility Complex Class I E (MHCE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV087Mo01 | Monoclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IP. |
| PAV087Mo01 | Polyclonal Antibody to Major Histocompatibility Complex Class I E (MHCE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV087Mo01 | CLIA Kit for Major Histocompatibility Complex Class I E (MHCE) | CLIA assay for Antigen Detection |
| ELV087Mo01 | ELISA Kit for Major Histocompatibility Complex Class I E (MHCE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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J. Immunol. 140:4024-4030(1988) [PubMed] [Europe PMC] [Abstract]
"Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences."
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E."
Mol. Cell 1:531-541(1998) [PubMed] [Europe PMC] [Abstract]
"Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data."
Tissue Antigens 60:206-212(2002) [PubMed] [Europe PMC] [Abstract]