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Ribonuclease A3 (RNASE3)

Rnase-A3; RnaseA3; ECP; RNS3; Ribonuclease,RNase A Family 3; Eosinophil Cationic Protein

Eosinophil cationic protein, like eosinophil-derived neurotoxin, is localized to the granule matrix of the eosinophil. Both proteins possess neurotoxic, helminthotoxic, and ribonucleolytic activities. The cDNA sequences of the genes encoding these 2 proteins and the deduced amino acid sequences indicate that the genes belong to the ribonuclease gene superfamily. Hamann et al. (1990) demonstrated remarkable similarities of eosinophil-derived neurotoxin and eosinophil cationic protein, symbolized RNS2 and RNS3, respectively, in noncoding sequences, introns, and flanking regions, as well as the previously known coding regions. A single intron in the 5-prime untranslated region and an intronless coding region appear to be features common to many members of the RNase gene superfamily.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V081Hu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies MV081Hu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
PV081Hu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
LV081Hu72 Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits KEV081Hu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V081Mu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies MV081Mu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
PV081Mu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
LV081Mu72 Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits KEV081Mu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V081Ra01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies MV081Ra21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
PV081Ra01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
LV081Ra72 Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ribonuclease A3 (RNASE3) Bioactivity
Antibodies NONE Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ribonuclease A3 (RNASE3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ribonuclease A3 (RNASE3) CLIA assay for Antigen Detection

Reference

"Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity."
J. Exp. Med. 170:163-176(1989) [PubMed] [Europe PMC] [Abstract]

"Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily."
Genomics 7:535-546(1990) [PubMed] [Europe PMC] [Abstract]

"Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases."
J. Immunol. 143:952-955(1989) [PubMed] [Europe PMC] [Abstract]

"Sequence variation at two eosinophil-associated ribonuclease loci in humans."
Genetics 156:1949-1958(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease."
Proc. Natl. Acad. Sci. U.S.A. 83:3146-3150(1986) [PubMed] [Europe PMC] [Abstract]

"Antibiotic proteins of human polymorphonuclear leukocytes."
Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]

"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]

"Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment."
Biochem. J. 421:425-434(2009) [PubMed] [Europe PMC] [Abstract]

"Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region."
Biomacromolecules 11:1983-1990(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of eosinophil cationic protein at 2.4 A resolution."
Biochemistry 38:16794-16801(1999) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution."
J. Mol. Biol. 300:1297-1307(2000) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site."
Biochemistry 41:12100-12106(2002) [PubMed] [Europe PMC] [Abstract]