Major Vault Protein (MVP)
LRP; VAULT1; Lung resistance-related protein
Major vault protein is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells.
The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.L-MVP, that contains a 41-bp stretch in the 5-prime region that is intronic in the shorter S-MVP splice variant. This 41-bp stretch introduces an upstream ORF encoding a deduced 18-amino acid peptide.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | V075Hu01 | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | MV075Hu21 | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
PV075Hu01 | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | KEV075Hu | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Major Vault Protein (MVP) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Major Vault Protein (MVP) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Major Vault Protein (MVP) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Major Vault Protein (MVP) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Major Vault Protein (MVP) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Major Vault Protein (MVP) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Major Vault Protein (MVP) | CLIA assay for Antigen Detection |
Reference
"The drug resistance-related protein LRP is the human major vault protein."
Nat. Med. 1:578-582(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter."
Biochem. Biophys. Res. Commun. 278:125-133(2000) [PubMed] [Europe PMC] [Abstract]
"A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant."
FEBS Lett. 494:99-104(2001) [PubMed] [Europe PMC] [Abstract]
, Submitted (JAN-2005) to UniProtKB
"Vaults and telomerase share a common subunit, TEP1."
J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]
"PTEN associates with the vault particles in HeLa cells."
J. Biol. Chem. 277:40247-40252(2002) [PubMed] [Europe PMC] [Abstract]
"The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling."
J. Biol. Chem. 279:29374-29385(2004) [PubMed] [Europe PMC] [Abstract]
"A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway."
Biochem. Biophys. Res. Commun. 347:288-296(2006) [PubMed] [Europe PMC] [Abstract]
"Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling."
FEBS J. 273:793-804(2006) [PubMed] [Europe PMC] [Abstract]
"The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals."
J. Cell Sci. 119:459-469(2006) [PubMed] [Europe PMC] [Abstract]
"Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1."
Mol. Cell. Biol. 28:7066-7080(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of a two-repeat fragment of major vault protein."
J. Mol. Biol. 356:444-452(2006) [PubMed] [Europe PMC] [Abstract]