Minichromosome Maintenance Deficient 2 (MCM2)

BM28; CCNL1; CDCL1; Cdc19; Mitotin; DNA Replication Licensing Factor MCM2; Nuclear protein BM28

SPN	V071
HGNC	6944
MGI	105380
PubMed	9371513
RGD	1305577
UniProt	P49736
Wiki	MCM2

DNA replication licensing factor MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.

This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

Reference

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