Myeloid Cell Nuclear Differentiation Antigen (MNDA)

PYHIN3

SPN	V065
HGNC	7183
PubMed	15778972
UniProt	P41218
Wiki	MNDA

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha.

MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Reference

"Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha."
J. Cell. Biochem. 49:82-92(1992) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins."
J. Cell. Biochem. 48:190-202(1992) [PubMed] [Europe PMC] [Abstract]

"The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells."
Blood 83:2153-2162(1994) [PubMed] [Europe PMC] [Abstract]

"Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage."
J. Cell. Biochem. 54:198-206(1994) [PubMed] [Europe PMC] [Abstract]

"The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression."
Immunogenetics 41:40-43(1995) [PubMed] [Europe PMC] [Abstract]

"Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding."
J. Cell. Biochem. 70:489-506(1998) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the pyrin (PAAD-DAPIN) domain in human myeloid cell nuclear differentiation antigen."
Submitted (JUN-2006) to the PDB data bank