Interferon Regulatory Factor 8 (IRF8)

H-ICSBP; ICS-BP; ICSBP1; Interferon Consensus Sequence-Binding Protein 1

SPN	V064
HGNC	5358
MGI	96395
PubMed	21587231
RGD	1312024
UniProt	Q02556
Wiki	IRF8

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha; and IFN-beta;. IRF family proteins also control expression of IFN-alpha; and IFN-beta;-regulated genes that are induced by viral infection..
Mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP KO mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.

Reference

"Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes."
J. Biol. Chem. 267:25589-25596(1992) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome."
J. Biol. Chem. 275:39081-39089(2000) [PubMed] [Europe PMC] [Abstract]

"BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"IRF8 mutations and human dendritic-cell immunodeficiency."
N. Engl. J. Med. 365:127-138(2011) [PubMed] [Europe PMC] [Abstract]