Junctional Adhesion Molecule 2 (JAM2)

CD322; JAM-B; JAMB; VE-JAM; VEJAM; Junctional adhesion molecule B; Vascular endothelial junction-associated molecule

SPN	V057
HGNC	14686
MGI	1933820
PubMed	12239159
RGD	1561692
UniProt	P57087
Wiki	JAM2

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Reference

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