Rho Family GTPase 1 (RND1)
ARHS; RHO6; RHOS; Ras Homolog Gene Family Member S; Rho-related GTP-binding protein Rho6
Rnd1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).By screening a human fetal brain cDNA library using bovine Rnd1 as probe, Nobes et al. (1998) cloned RND1.
The deduced protein contains 232 amino acids and has a calculated molecular mass of 26 kD. It contains 3 guanine-binding motifs, 2 loops and a threonine involved in phosphate binding, and 3 major residues that coordinate magnesium in the GTP-bound state. However, RND1 lacks the residues important for the intrinsic GTPase activity of RAS .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Hu01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Hu01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Hu01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Hu01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Hu01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Mu01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Mu01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Mu01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Mu01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Mu01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Ra01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Ra01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Ra01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Ra01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Ra01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Ca01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Ca01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Ca01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Ca01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Ca01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Po01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Po01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Po01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Po01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Po01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Bo01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Bo01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Bo01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Bo01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Bo01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Rb01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Rb01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Rb01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Rb01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Rb01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV052Mo01 | Recombinant Rho Family GTPase 1 (RND1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV052Mo01 | Monoclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IP. |
| PAV052Mo01 | Polyclonal Antibody to Rho Family GTPase 1 (RND1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV052Mo01 | CLIA Kit for Rho Family GTPase 1 (RND1) | CLIA assay for Antigen Detection |
| ELV052Mo01 | ELISA Kit for Rho Family GTPase 1 (RND1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion."
J. Cell Biol. 141:187-197(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells."
Biochem. Biophys. Res. Commun. 278:604-608(2000) [PubMed] [Europe PMC] [Abstract]
"Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family."
FEBS Lett. 467:91-96(2000) [PubMed] [Europe PMC] [Abstract]
"Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers."
Mol. Cell. Biol. 22:2952-2964(2002) [PubMed] [Europe PMC] [Abstract]
"Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells."
J. Biol. Chem. 278:25671-25677(2003) [PubMed] [Europe PMC] [Abstract]
"Structure and function of the intracellular region of the plexin-B1 transmembrane receptor."
J. Biol. Chem. 284:35962-35972(2009) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of plexin A2 RBD in complex with RND1."
Submitted (JAN-2011) to the PDB data bank