Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7)

CDw328; CD328; p75; AIRM1; D-Siglec; QA79; SIGLEC-7; P75/AIRM1; Adhesion inhibitory receptor molecule 1; QA79 membrane protein

SPN	V051
HGNC	10876
MGI	1932475
PubMed	10764831
UniProt	Q9Y286
Wiki	SIGLEC7

The highest amino acid sequence similarity found was with the myeloid-specific CD33 molecule , and similar to other sialoadhesin molecules, AIRM1 appears to mediate sialic acid-dependent ligand recognition.

By analyzing genomic DNA samples derived from a panel of human/hamster somatic cell hybrids, Falco et al. (1999) mapped the SIGLEC7 gene to chromosome 19. They noted that other members of the sialoadhesin family map to chromosome 19, including CD33, SIGLEC6, SIGLEC5, myelin-associated glycoprotein (MAG), and CD22 . Therefore, SIGLEC7 is probably located on 19q13.3, where these other family members have been localized. Human tissues show strong expression of Siglec-7 mRNA in spleen, peripheral blood leukocytes, and liver.

Reference

"Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes."
J. Biol. Chem. 274:34089-34095(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells."
J. Exp. Med. 190:793-802(1999) [PubMed] [Europe PMC] [Abstract]

"Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily."
Glycobiology 10:431-438(2000) [PubMed] [Europe PMC] [Abstract]

"Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells."
Proc. Natl. Acad. Sci. U.S.A. 96:15091-15096(1999) [PubMed] [Europe PMC] [Abstract]

"Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression."
FEBS Lett. 498:116-120(2001) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family."
J. Biol. Chem. 278:3372-3377(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1."
Acta Crystallogr. D 60:401-403(2004) [PubMed] [Europe PMC] [Abstract]

"The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design."
Biochem. J. 397:271-278(2006) [PubMed] [Europe PMC] [Abstract]

"Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b."
J. Biol. Chem. 281:32774-32783(2006) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]