Prekallikrein (PK)
KLKB1; KLK3; Fletcher Factor; Kallikrein B,Plasma; Kininogenin; Plasma prekallikrein
Prekallikrein (PK), also known as Fletcher factor, is a 85,000 Mr serine protease that complexes with HK. Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain.
Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Hu01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Hu01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Hu01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Hu01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Hu01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Mu01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Mu01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Mu01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Mu01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Mu01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Ra01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Ra01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Ra01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Ra01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Ra01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Ca01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Ca01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Ca01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Ca01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Ca01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Po01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Po01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Po01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Po01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Po01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Bo01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Bo01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Bo01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Bo01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Bo01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Rb01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Rb01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Rb01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Rb01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Rb01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV039Mo01 | Recombinant Prekallikrein (PK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV039Mo01 | Monoclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IP. |
| PAV039Mo01 | Polyclonal Antibody to Prekallikrein (PK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV039Mo01 | CLIA Kit for Prekallikrein (PK) | CLIA assay for Antigen Detection |
| ELV039Mo01 | ELISA Kit for Prekallikrein (PK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats."
Biochemistry 25:2410-2417(1986) [PubMed] [Europe PMC] [Abstract]
"Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease."
Genomics 69:225-234(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule."
Biochemistry 30:2050-2056(1991) [PubMed] [Europe PMC] [Abstract]
"Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)."
Thromb. Haemost. 90:1040-1045(2003) [PubMed] [Europe PMC] [Abstract]
"A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region."
Eur. J. Haematol. 79:59-68(2007) [PubMed] [Europe PMC] [Abstract]