Mucin 7, Secreted (MUC7)

MG2; Mucin 7,Salivary; Apo-MG2; Salivary mucin-7

SPN	V033
HGNC	7518
PubMed	11378823
UniProt	Q8TAX7
Wiki	MUC7

The MUC7 gene encodes a small salivary mucin, which is thought to function in a protective capacity by promoting the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing.Bobek et al. (1996) found that the MUC7 gene spans approximately 10 kb and comprises 3 exons and 2 introns. Intron 1 is approximately 1.7 kb long and is located in the 5-prime untranslated region of the MUC7 cDNA.

Intron 2 spans approximately 6 kb and is located close to the boundary of the putative liter peptide and secreted protein. The entire region encoding the secreted peptide is located on exon 3, spanning approximately 2.2 kb.Bobek et al. (1993) described the isolation and characterization of overlapping cDNA clones that code for the low molecular weight glycoprotein core.

Reference

"Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)."
J. Biol. Chem. 268:20563-20569(1993) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural features of the low-molecular-mass human salivary mucin."
Biochem. J. 287:639-643(1992) [PubMed] [Europe PMC] [Abstract]

"Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa."
Crit. Rev. Oral Biol. Med. 4:315-323(1993) [PubMed] [Europe PMC] [Abstract]

"Genetic polymorphism of MUC7: allele frequencies and association with asthma."
Eur. J. Hum. Genet. 9:347-354(2001) [PubMed] [Europe PMC] [Abstract]