Selenoprotein P1, Plasma (SEPP1)

SEPP; SeP; SEP-P1; SELP

SPN	V032
HGNC	10751
MGI	894288
PubMed	24161883
RGD	3660
UniProt	P49908
Wiki	SEPP1

Selenoprotein P is a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.

Reference

"Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA."
Proc. Natl. Acad. Sci. U.S.A. 90:537-541(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification of selenoprotein P from human plasma."
Biochim. Biophys. Acta 1204:243-249(1994) [PubMed] [Europe PMC] [Abstract]

"A novel method for the purification of selenoprotein P from human plasma."
Arch. Biochem. Biophys. 357:326-330(1998) [PubMed] [Europe PMC] [Abstract]

"Selenoprotein P: properties, functions, and regulation."
Arch. Biochem. Biophys. 376:433-438(2000) [PubMed] [Europe PMC] [Abstract]

"Selenoprotein P. A selenium-rich extracellular glycoprotein."
J. Nutr. 124:1891-1897(1994) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]