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Vitamin D Binding Protein (DBP)

GC; VDBG; VDBP; Group-Specific Component; Gc-globulin

Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells. Human GC is a glycosylated alpha-globulin, ~58 kDa in size. Its 458 amino acids are coded for by 1690 nucleotides on chromosome 4 (4q11–q13). The primary structure contains 28 cysteine residues forming multiple disulfide bonds. GC contains 3 domains.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V031Hu01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies MV031Hu22 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PV031Hu01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
LV031Hu71 Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits KEV031Hu ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
KCV031Hu CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V031Mu01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PV031Mu01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
LV031Mu71 Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits KEV031Mu ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V031Ra01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies MV031Ra22 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PV031Ra01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
LV031Ra71 Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vitamin D Binding Protein (DBP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vitamin D Binding Protein (DBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vitamin D Binding Protein (DBP) CLIA assay for Antigen Detection

Reference

"Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family."
J. Clin. Invest. 76:2420-2424(1985) [PubMed] [Europe PMC] [Abstract]

"Human group-specific component (Gc) is a member of the albumin family."
Proc. Natl. Acad. Sci. U.S.A. 82:7994-7998(1985) [PubMed] [Europe PMC] [Abstract]

"Sequence and organization of the human vitamin D-binding protein gene."
Biochim. Biophys. Acta 1216:385-394(1993) [PubMed] [Europe PMC] [Abstract]

"Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family."
Genomics 16:751-754(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals."
Gene 54:285-290(1987) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein."
Biochim. Biophys. Acta 871:189-198(1986) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component)."
Biochemistry 18:1611-1617(1979) [PubMed] [Europe PMC] [Abstract]

"Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany."
Vox Sang. 68:50-54(1995) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types."
Hum. Genet. 89:401-406(1992) [PubMed] [Europe PMC] [Abstract]

"A structural basis for the unique binding features of the human vitamin D-binding protein."
Nat. Struct. Biol. 9:131-136(2002) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]