Uridine Phosphorylase 1 (UPP1)

UDRPASE; UP; UPASE

SPN	V030
HGNC	12576
MGI	1097668
PubMed	15714138
RGD	1305566
UniProt	Q16831
Wiki	UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate.

The recombinant UP expressed in COS-7 cells demonstrated specific enzyme activity with uridine as the substrate; this activity was inhibited by a competitive inhibitor. Northern blot analysis with the cDNA as a probe demonstrated high levels of mRNA expression in several tumor cell lines but a very low level in a normal cell line.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Hu01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Hu01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Hu01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Hu01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Hu01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Mu01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Mu01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Mu01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Mu01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Mu01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Ra01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Ra01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Ra01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Ra01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Ra01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Ca01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Ca01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Ca01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Ca01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Ca01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Po01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Po01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Po01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Po01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Po01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Bo01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Bo01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Bo01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Bo01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Bo01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Rb01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Rb01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Rb01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Rb01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Rb01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV030Mo01	Recombinant Uridine Phosphorylase 1 (UPP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV030Mo01	Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IP.
Antibodies	PAV030Mo01	Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1)	WB; IHC; ICC; IF.
Assay Kits	CLV030Mo01	CLIA Kit for Uridine Phosphorylase 1 (UPP1)	CLIA assay for Antigen Detection
Assay Kits	ELV030Mo01	ELISA Kit for Uridine Phosphorylase 1 (UPP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and expression of human uridine phosphorylase."
Biochem. Biophys. Res. Commun. 216:265-272(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy."
BMC Struct. Biol. 9:14-14(2009) [PubMed] [Europe PMC] [Abstract]

"Active site conformational dynamics in human uridine phosphorylase 1."
PLoS ONE 5:E12741-E12741(2010) [PubMed] [Europe PMC] [Abstract]