Complement Component 6 (C6)
C6 is 1 of 5 late-acting proteins of complement that participate in assembly and function of the MAC (DiScipio and Hugli, 1989). The deduced C6 protein contains 934 amino acids, including a 21-amino acid N-terminal signal sequence and 2 N-glycosylation sites. The mature 913-amino acid C6 protein shares 29% amino acid identity with C7 , and 55 of 56 cysteines in C7 match those in C6.
The C6 polypeptide chain is cross-linked by 32 disulfide bonds, and most cysteines are located in short, discrete segments that exhibit homology with a variety of proteins, including thrombospondin, low density lipoprotein receptor(LDLR), epidermal growth factor (EGF), and complement factors H (CFH) and I (CFI ).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V027Hu01 | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | MV027Hu22 | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| PV027Hu01 | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV027Hu | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Complement Component 6 (C6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Complement Component 6 (C6) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Complement Component 6 (C6) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Complement Component 6 (C6) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Complement Component 6 (C6) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Complement Component 6 (C6) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Complement Component 6 (C6) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Complement Component 6 (C6) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Complement Component 6 (C6) | CLIA assay for Antigen Detection |
Reference
"Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6."
J. Biol. Chem. 264:18041-18051(1989) [PubMed] [Europe PMC] [Abstract]
"The molecular architecture of human complement component C6."
J. Biol. Chem. 264:16197-16206(1989) [PubMed] [Europe PMC] [Abstract]
"Structure of the human C6 gene."
Biochemistry 32:6198-6205(1993) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structural homology of complement protein C6 with other channel-forming proteins of complement."
Proc. Natl. Acad. Sci. U.S.A. 86:2799-2803(1989) [PubMed] [Europe PMC] [Abstract]
"Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement."
Biochim. Biophys. Acta 1342:13-18(1997) [PubMed] [Europe PMC] [Abstract]
"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC)."
J. Biol. Chem. 287:10210-10222(2012) [PubMed] [Europe PMC] [Abstract]
"Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B."
Biochem. Biophys. Res. Commun. 194:458-464(1993) [PubMed] [Europe PMC] [Abstract]
"Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism."
Eur. J. Pediatr. 164:177-179(2005) [PubMed] [Europe PMC] [Abstract]