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Keratin 17 (KRT17)

PC2; CK17; K17; PC; PCHC1; Cytokeratin 17; Keratin, type I cytoskeletal 17

Keratin 17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.The functional KRT17 gene differs from the pseudogenes by the extent of methylation of certain DNA sequences in the 5-prime upstream region. The KRT17 gene encodes a polypeptide of 432 amino acids with a calculated molecular weight of 48,000. Using S1-nuclease protection assays and RNAs from several cell lines, Troyanovsky et al. identified a single transcriptional start point 26 nucleotides downstream from a TATA box element. Synthesis of cytokeratin-17 seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cell.'

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Hu01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Hu01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Hu01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Hu01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Hu01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Mu01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Mu01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Mu01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Mu01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Mu01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Ra01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Ra01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Ra01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Ra01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Ra01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Ca01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Ca01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Ca01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Ca01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Ca01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Po01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Po01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Po01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Po01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Po01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Bo01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Bo01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Bo01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Bo01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Bo01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Rb01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Rb01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Rb01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Rb01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Rb01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV019Mo01 Recombinant Keratin 17 (KRT17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV019Mo01 Monoclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IP.
PAV019Mo01 Polyclonal Antibody to Keratin 17 (KRT17) WB; IHC; ICC; IF.
Assay Kits CLV019Mo01 CLIA Kit for Keratin 17 (KRT17) CLIA assay for Antigen Detection
ELV019Mo01 ELISA Kit for Keratin 17 (KRT17) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

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J. Am. Acad. Dermatol. 54:992-1002(2006) [PubMed] [Europe PMC] [Abstract]

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"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion."
J. Biol. Chem. 286:42403-42413(2011) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex."
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"Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2."
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"Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2."
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"Novel keratin 17 mutations in pachyonychia congenita type 2."
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"Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."
J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]

"A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2."
J. Invest. Dermatol. 118:545-547(2002) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2."
J. Invest. Dermatol. 122:892-895(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2."
J. Dermatol. Sci. 38:60-63(2005) [PubMed] [Europe PMC] [Abstract]

"The genetic basis of pachyonychia congenita."
J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]

"Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity."
J. Dermatol. 33:161-164(2006) [PubMed] [Europe PMC] [Abstract]

"A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."
J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]

"A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb."
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"Novel missense mutation of keratin in Chinese family with steatocystoma multiplex."
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"A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2."
Int. J. Dermatol. 52:117-119(2013) [PubMed] [Europe PMC] [Abstract]

"Novel mutation (p.L91P, c.272T>C) of keratin 17 in a case with pachyonychia congenita type 2."
J. Dermatol. 40:757-758(2013) [PubMed] [Europe PMC] [Abstract]