Complement Component 9 (C9)
Activation of the complement system results in formation of the membrane attack complex (MAC) on the membranes of target cells. The complex is assembled by sequential addition of 1 molecule each of C5b, C6, C7, and C8 and 6 to 16 molecules of the ninth component, C9.
DiScipio et al. (1984) screened a human liver cDNA library by the colony-hybridization technique using 2 radiolabelled oligonucleotide probes that correspond to known regions of the C9 amino acid sequence. The cDNA coding for C9 was sequenced and the protein sequence--537 amino acids in a single polypeptide chain--was derived. The amino-terminal half of C9 is predominantly hydrophilic and the carboxyl-terminal half is more hydrophobic.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Hu01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Hu01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Hu01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Hu01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Hu01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Mu01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Mu01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Mu01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Mu01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Mu01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Ra01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Ra01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Ra01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Ra01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Ra01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Ca01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Ca01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Ca01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Ca01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Ca01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Po01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Po01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Po01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Po01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Po01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Bo01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Bo01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Bo01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Bo01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Bo01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Rb01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Rb01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Rb01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Rb01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Rb01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV018Mo01 | Recombinant Complement Component 9 (C9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV018Mo01 | Monoclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IP. |
| PAV018Mo01 | Polyclonal Antibody to Complement Component 9 (C9) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV018Mo01 | CLIA Kit for Complement Component 9 (C9) | CLIA assay for Antigen Detection |
| ELV018Mo01 | ELISA Kit for Complement Component 9 (C9) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The sequence and topology of human complement component C9."
EMBO J. 4:375-382(1985) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9."
Proc. Natl. Acad. Sci. U.S.A. 81:7298-7302(1984) [PubMed] [Europe PMC] [Abstract]
"Relationships between the gene and protein structure in human complement component C9."
Biochemistry 27:6529-6534(1988) [PubMed] [Europe PMC] [Abstract]
"Heterogeneity in the genetic basis of human complement C9 deficiency."
Immunogenetics 48:144-147(1998) [PubMed] [Europe PMC] [Abstract]
"The architecture of complement component C9 and poly(C9)."
J. Biol. Chem. 260:14802-14809(1985) [PubMed] [Europe PMC] [Abstract]
"Identification of disulfide bonds in the ninth component (C9) of human complement."
FEBS Lett. 380:8-12(1996) [PubMed] [Europe PMC] [Abstract]
"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin."
Mol. Immunol. 27:589-602(1990) [PubMed] [Europe PMC] [Abstract]
"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration."
Nat. Genet. 45:1366-1370(2013) [PubMed] [Europe PMC] [Abstract]